Bone Grafts and Substitutes Market by Product (Allografts, Bone Grafts Substitutes and Cell Based Matrices), by Application (Spinal Fusion, Long Bone, Foot & Ankle, Craniomaxilofacial, Joint Reconstruction and Dental Bone Grafting) - Global Opportunity Analysis and Industry Forecast, 2014-2022

Bone Grafts and Substitutes Market by Product (Allografts, Bone Grafts Substitutes and Cell Based Matrices), by Application (Spinal Fusion, Long Bone,

Category : Medical Devices
Published On : November  2016
Pages : 130



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Bone grafts are implantable materials that promote bone healing through its osteoconductive, osteogenic, and osteoinductive mechanisms. The bone grafts are used in surgical procedures such as spinal fusion surgeries, bone replacement, ensuring new bone formation and repair of bone fractures. Moreover, bone grafting also has applications in treatment of various bone related disorders such as congenital pseudoarthrosis, dental bone grafting problems, and complex fractures. Allografts, synthetic bone grafts, and demineralized bone matrix are the most commonly used bone grafts worldwide.

The world bone grafts and substitutes market was $2,443 million in 2015 and is expected to reach $3,397 million by 2022 with a CAGR of 4.1% during the forecast period. Rise in incidences of musculoskeletal disorders, development of biocompatible synthetic bone grafts, technological advancements in medical field leading to a shift from autograft to allograft drive the bone grafts and substitutes market. According to National Health Interview Survey, in 2012, around 126 million adults were affected by musculoskeletal disorders in U.S. Moreover, the 2014-2015 estimates from Labor Force Survey (LFS) showed 553,000 cases out of a total of 1,243,000 for all work related musculoskeletal disorder. These estimates are expected to boost the demand for bone grafts and its substitutes in the coming years. In addition, increase in cases of lifestyle disorders such as diabetes and obesity add to the risk of developing degenerative joint diseases that further fuel the growth of the market.

On the other hand, high cost of surgeries and ethical issues related with bone grafting procedures restrict the market growth. Conversely, emerging markets, rise in interests of key players towards R&D activities in bone grafts and its substitutes, and increase in demand for orthopedic procedures particularly in geriatric population is expected to provide lucrative opportunities for growth of the market in near future.

The report segments the market based upon product type, application, and geography. Based on product type, the market is segmented into allografts, bone grafts substitutes, and cell based matrices. The allografts are further categorized to machined allografts and demineralized bone matrix. The bone graft substitutes segment is further classified into bone morphogenic proteins (BMP) and synthetic bone grafts. Based on applications, the market is segmented into spinal fusion, trauma, craniomaxilofacial, joint reconstruction, and dental bone grafting. Geographically, the market is segmented into four major regions, namely, North America, Europe, Asia-Pacific, and LAMEA.

KEY BENEFITS FOR STAKEHOLDERS

  • The study provides an in-depth analysis of the market along with current trends and future estimations to elucidate the imminent investment pockets.
  • The report provides a quantitative analysis for the period of 2014-2022 to enable stakeholders to capitalize on the prevailing market opportunities.
  • Extensive analysis of the market based on products helps understand the type of devices used to treat musculoskeletal disorders and degenerative joints diseases.
  • Competitive intelligence highlights the business practices followed by leading players across various regions.
  • Comprehensive analysis of all geographic regions help determine the prevailing opportunities in these regions.
  • Key market players and their strategies are analyzed to understand the competitive outlook of the overall market.
  • Extensive analysis of the market is conducted by following key product positioning and monitoring the top contenders within the market framework.

KEY MARKET SEGMENTS

By Product

  • Allografts
  • Machined allografts
  • Demineralized bone matrix
  • Bone Grafts Substitutes
  • Bone morphogenic proteins (BMP)
  •  Synthetic bone grafts
  • Cell based matrices

By Application

  • Spinal fusion
  • Trauma
  • Craniomaxilofacial
  • Joint reconstruction
  • Dental Bone Grafting

By Geography

  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • Germany
    • France
    • UK
    • Italy
    • Spain
    • Rest of Europe
  • Asia-Pacific
    • Japan
    • China
    • India
    • Australia
    • South Korea
    • Rest of Asia-Pacific
  • LAMEA
    • Brazil
    • South Africa
    • Israel
    • Saudi Arabia
    • Rest of LAMEA

List of key players profiled in the report

  • Medtronic plc
  • Stryker Corporation
  • DePuy Synthes  
  • Integra Lifesciences Holdings Corporation
  • Zimmer Biomet Holdings, Inc.
  • Xtant Medical Holdings, Inc. (Bacterin)
  • Arthrex, Inc.
  • Baxter International Inc.
  • Musculoskeletal Transplant Foundation (MTF)
  • Wright Medical Group N.V.

List of other players in the value chain

  • NovaBone Products
  • LLC, BonAlive Biomaterials Ltd.
  • Sigma Graft Biomaterials
  • Pioneer Surgical Technology Inc.
  • RTI Biologics, Inc.
  • Orthofix International N.V.
  • Citagenix Inc.
  • Heraeus Medical GmbH
  • Graftys SA
  • NuVasive, Inc.

*Profiles of these players are not included. The same will be included on request.

CHAPTER 1 INTRODUCTION

1.1 Report description
1.2 Key benefits
1.3 Key market segments
1.4 Research methodology

1.4.1 Secondary research
1.4.2 Primary research
1.4.3 Analyst tools and models

CHAPTER 2 EXECUTIVE SUMMARY

2.1 CXperspective

CHAPTER 3 MARKET OVERVIEW

3.1 Market definition and scope
3.2 Key findings

3.2.1 Top investment pockets
3.2.2 Top winning strategies

3.3 Market share analysis, 2015
3.4 Market dynamics

3.4.1 Drivers

3.4.1.1 Increasing incidences of musculoskeletal conditions
3.4.1.2 Technological advancements in medical devices leading ta shift from autograft tallograft
3.4.1.3 Development of biocompatible synthetic bone grafts
3.4.1.4 Obesity and diabetes tincrease the risk of denegenerative joint diseases

3.4.2 Restraints

3.4.2.1 High cost of surgeries
3.4.2.2 Ethical issues related with bone grafting procedures

3.4.3 Opportunities

3.4.3.1 Emerging markets toffer lucrative growth opportunities

3.5 Government Regulations

3.5.1 FDA
3.5.2 Health Canada
3.5.3 CE Mark
3.5.4 Ministry of Health, Labor and Welfare (MHLW)
3.5.5 Therapeutic Goods Administration (TGA)

3.6 Reimbursement Scenario

3.6.1 U.S.
3.6.2 Europe
3.6.3 Asia-Pacific
3.6.4 LAMEA

CHAPTER 4 WORLD BONE GRAFTS AND SUBSTITUTES MARKET, BY PRODUCT

4.1. OVERVIEW

4.1.1. Market size and forecast

4.2. ALLOGRAFTS

4.2.1. Key market trends
4.2.2. Key growth factors and opportunities
4.2.3. Market size and forecast
4.2.4. Demineralized Bone Matrix (DBM)

4.2.4.1. Market size and forecast

4.2.5. Machined Allografts

4.2.5.1. Market size and forecast

4.3. BONE GRAFT SUBSTITUTES

4.3.1. Key market trends
4.3.2. Key growth factors and opportunities
4.3.3. Market size and forecast
4.3.4. Bone Morphogenic Proteins (BMP)

4.3.4.1. Market size and forecast

4.3.5. Synthetic Bone Grafts

4.3.5.1. Market size and forecast

4.4.CELL BASED MATRICES (CBM)

4.4.1. Key market trends
4.4.2. Key growth factors and opportunities
4.4.3. Market size and forecast

CHAPTER 5 WORLD BONE GRAFTS AND SUBSTITUTES MARKET, BY APPLICATION

5.1 Overview

5.1.1 Market size and forecast

5.2 Spinal Fusion

5.2.1 Market size and forecast

5.3 Trauma

5.3.1 Market size and forecast

5.4 Craniomaxillofacial Surgery

5.4.1 Market size and forecast

5.5 Joint Reconstruction

5.5.1 Market size and forecast

5.6 Dental Bone Grafting

5.6.1 Market size and forecast

CHAPTER 6 WORLD BONE GRAFT AND SUBSTITUTES MARKET, BY REGION

6.1 Overview

6.1.1 Market size and forecast

6.2 North America

6.2.1 Key market trends
6.2.2 Key growth factors and opportunities
6.2.3 Market size and forecast
6.2.4 U.S. market size and forecast
6.2.5 Canada market size and forecast
6.2.6 Mexicmarket size and forecast

6.3 Europe

6.3.1 Key market trends
6.3.2 Key growth factors and opportunities
6.3.3 Market size and forecast
6.3.4 Germany market size and forecast
6.3.5 France market size and forecast
6.3.6 U.K. market size and forecast
6.3.7 Italy market size and forecast
6.3.8 Spain market size and forecast
6.3.9 Rest of Europe market size and forecast

6.4 Asia-Pacific

6.4.1 Key market trends
6.4.2 Key growth factors and opportunities
6.4.3 Market size and forecast
6.4.4 Japan market size and forecast
6.4.5 China market size and forecast
6.4.6 India market size and forecast
6.4.7 Australia market size and forecast
6.4.8 South Korea market size and forecast
6.4.9 Rest of Asia-Pacific market size and forecast

6.5 LAMEA

6.5.1 Key market trends
6.5.2 Key growth factors and opportunities
6.5.3 Market size and forecast
6.5.4 Brazil market size and forecast
6.5.5 South Africa market size and forecast
6.5.6 Saudi Arabia market size and forecast
6.5.7 Israel market size and forecast
6.5.8 Rest of LAMEA market size and forecast

CHAPTER 7 COMPANY PROFILES

7.1 Baxter International Inc.

7.1.1 Company Overview
7.1.2 Company snapshot
7.1.3 Operating business segments
7.1.4 Business performance

7.2 Integra Lifesciences Holdings Corporation

7.2.1 Company overview
7.2.2 Company snapshot
7.2.3 Operating business segments
7.2.4 Business performance
7.2.5 Key strategic moves & developments

7.3 Stryker Corporation

7.3.1 Company overview
7.3.2 Company snapshot
7.3.3 Operating business segments
7.3.4 Business performance
7.3.5 Key strategic moves & developments

7.4 Zimmer Biomet Holdings, Inc.

7.4.1 Company Overview
7.4.2 Company Snapshot
7.4.3 Operating business segments
7.4.4 Business performance
7.4.5 Key Strategic Moves & Developments

7.5 Wright Medical Group N.V.

7.5.1 Company overview
7.5.2 Company snapshot
7.5.3 Operating business segments
7.5.4 Business performance
7.5.5 Key strategic moves & developments

7.6 Xtant Medical Holdings, Inc.

7.6.1 Company overview
7.6.2 Company snapshot
7.6.3 Operating business segments
7.6.4 Business performance
7.6.5 Key strategic moves & developments

7.7 Johnson & Johnson

7.7.1 Company overview
7.7.2 Company snapshot
7.7.3 Operating business segments
7.7.4 Business performance
7.7.5 Key strategic moves & developments

7.8 Arthrex, Inc

7.8.1 Company overview
7.8.2 Company snapshot
7.8.3 Operating business segments
7.8.4 Key strategic moves & developments

7.9 Musculoskeletal Transplant Foundation

7.9.1 Company overview
7.9.2 Company snapshot
7.9.3 Operating business segments

7.10 Medtronic plc

7.10.1 Company Overview
7.10.2 Company Snapshot
7.10.3 Operating Business Segments
7.10.4 Business Performance
7.10.5 Key Strategic Moves & Developments

Other players* in the value chain include:

  • NovaBone Products
  • LLC, BonAlive Biomaterials Ltd.
  • Sigma Graft Biomaterials
  • Pioneer Surgical Technology Inc.
  • RTI Biologics, Inc.
  • Orthofix International N.V.
  • Citagenix Inc.
  • Heraeus Medical GmbH
  • Graftys SA
  • NuVasive, Inc.

*Profiles of these players are not included. The same will be included on request.

List of Charts

FIG. 1 MARKET SEGMENTATION
FIG. 2 TOP WINNING STRATEGIES: PERCENTAGE DISTRIBUTION (2014-2016)
FIG. 3 TOP WINNING STRATEGIES: NATURE AND TYPE
FIG. 4 MARKET SHARE ANALYSIS, BONE GRAFTS AND SUBSTITUTES, 2015
FIG. 5 MARKET SHARE ANALYSIS, MACHINED ALLOGRAFTS, 2015
FIG. 6 MARKET SHARE ANALYSIS, DEMINERALISED BONE MATRIX, 2015
FIG. 7 MARKET SHARE ANALYSIS, BONE MORPHOGENIC PROTEINS, 2015
FIG. 8 MARKET SHARE ANALYSIS, CELL BASED MATRICES, 2015
FIG. 9 MARKET SHARE ANALYSIS, SYNTHETIC BONE GRAFTS, 2015
FIG. 10 MARKET SHARE ANALYSIS, 2015
FIG. 11 MARKET DYNAMICS
FIG. 12 TOP IMPACTING FACTORS: WORLD BONE GRAFT AND SUBSTITUTES MARKET, 2014-2022
FIG. 13 WORLD BONE GRAFT AND SUBSTITUTES MARKET, BY TYPE
FIG. 14 U.S.: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 15 CANADA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 16 MEXICO: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 17 GERMANY: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 18 FRANCE: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 19 UK: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 20 ITALY: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 21 SPAIN: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 22 REST OF EUROPE: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 23 JAPAN: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 24 CHINA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 25 INDIA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 26 AUSTRALIA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 27 SOUTH KOREA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 28 REST OF ASIA-PACIFIC: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 29 BRAZIL: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 30 SOUTH AFRICA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 31 SAUDI ARABIA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 32 ISRAEL: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 33 REST OF LAMEA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), 2014-2022
FIG. 34 BAXTER: NET SALES ($MILLION), 20132015
FIG. 35 BAXTER: NET SALES, BY BUSINESS SEGMENT (%), 2015
FIG. 36 BAXTER: NET SALES, BY GEOGRAPHY (%), 2015
FIG. 37 INTEGRA: NET SALES ($MILLION), 20132015
FIG. 38 INTEGRA: NET SALES, BY SEGMENT (%), 2015
FIG. 39 INTEGRA: NET SALES, BY GEOGRAPHY (%), 2015
FIG. 40 INTEGRA: STRATEGY SHARE (%), 2014-2016
FIG. 41 STRYKER: NET SALES ($MILLION), 20132015
FIG. 42 STRYKER: NET SALES, BY SEGMENT (%), 2015
FIG. 43 STRYKER: NET SALES, BY GEOGRAPHY (%), 2015
FIG. 44 STRYKER: STRATEGY SHARE (%), 20112015
FIG. 45 ZIMMER BIOMET: NET SALES ($MILLION), 20132015
FIG. 46 ZIMMER BIOMET: NET SALES, BY PRODUCT TYPE CATEGORY (%), 2015
FIG. 47 ZIMMER BIOMET: NET SALES, BY GEOGRAPHY (%), 2015
FIG. 48 ZIMMER BIOMET: STRATEGY SHARE (%), 2014-2016
FIG. 49 WRIGHT: NET SALES ($MILLION), 20132015
FIG. 50 WRIGHT: NET SALES, BY SEGMENT (%), 2015
FIG. 51 WRIGHT: NET SALES, BY GEOGRAPHY (%), 2015
FIG. 52 WRIGHT: STRATEGY SHARE (%), 20122015
FIG. 53 XTANT MEDICAL: NET SALES ($MILLION), 20132015
FIG. 54 XTANT MEDICAL: NET SALES, BY SEGMENT (%), 2015
FIG. 55 XTANT MEDICAL: NET SALES, BY GEOGRAPHY (%), 2015
FIG. 56 XTANT MEDICAL: STRATEGY SHARE (%), 2014-2016
FIG. 57 JOHNSON & JOHNSON: NET SALES ($MILLION), 20132015
FIG. 58 JOHNSON & JOHNSON: NET SALES, BY BUSINESS SEGMENT (%), 2015
FIG. 59 JOHNSON & JOHNSON: NET SALES, BY GEOGRAPHY (%), 2015
FIG. 60 MEDTRONIC: NET SALES ($MILLION), 2014-2016
FIG. 61 MEDTRONIC: NET SALES, BY SEGMENT (%), 2016
FIG. 62 MEDTRONIC: NET SALES, BY GEOGRAPHY (%), 2016

List of Tables

TABLE 1 WORLD BONE GRAFTS AND SUBSTITUTES MARKET, BY TYPE ($MILLION), 2014-2022
TABLE 2 ALLOGRAFT MARKET, BY TYPE ($MILLION), 2014-2022
TABLE 3 DEMINERALIZED BONE MATRIX, BY REGION ($MILLION), 2014-2022
TABLE 4 MACHINED ALLOGRAFTS, BY REGION ($MILLION), 2014-2022
TABLE 5 BONE GRAFTS SUBSTITUTES MARKET, BY TYPE ($MILLION), 2014-2022
TABLE 6 BONE MORPHOGENETIC PROTEIN, BY REGION ($MILLION), 2014-2022
TABLE 7 SYNTHETIC BONE GRAFTS, BY REGION ($MILLION), 2014-2022
TABLE 8 CELL BASED MATRICES MARKET, BY REGION ($MILLION), 2014-2022
TABLE 9 WORLD BONE GRAFTS AND SUBSTITUTES MARKET, BY APPLICATION ($MILLION), 2014-2022
TABLE 10 WORLD SPINAL FUSION MARKET, BY REGION ($MILLION), 2014-2022
TABLE 11 WORLD TRAUMA MARKET ($MILLION), BY REGION, 2014-2022
TABLE 12 WORLD CRANIOMAXILLOFACIAL MARKET ($MILLION) BY REGION, 2014-2022
TABLE 13 WORLD JOINT RECONSTRUCTION MARKET ($MILLION), BY REGION, 2014-2022
TABLE 14 WORLD DENTAL BONE GRAFTING MARKET ($MILLION), BY REGION, 2014-2022
TABLE 15 WORLD BONE GRAFT AND SUBSTITUTES MARKET ($MILLION), BY REGION, 2014-2022
TABLE 16 NORTH AMERICA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), BY COUNTRY, 2014-2022
TABLE 17 NORTH AMERICA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), BY TYPE, 2014-2022
TABLE 18 NORTH AMERICA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), BY APPLICATION, 2014-2022
TABLE 19 EUROPE: BONE GRAFTS AND SUBSTITUTES ($MILLION), BY COUNTRY, 2014-2022
TABLE 20 EUROPE: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), BY TYPE, 2014-2022
TABLE 21 EUROPE: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), BY APPLICATION, 2014-2022
TABLE 22 ASIA-PACIFIC: BONE GRAFTS AND SUBSTITUTES ($MILLION), BY COUNTRY, 2014-2022
TABLE 23 ASIA-PACIFIC: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), BY TYPE, 2014-2022
TABLE 24 ASIA-PACIFIC: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), BY APPLICATION, 2014-2022
TABLE 25 LAMEA: BONE GRAFTS AND SUBSTITUTES ($MILLION), BY COUNTRY, 2014-2022
TABLE 26 LAMEA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), BY TYPE, 2014-2022
TABLE 27 LAMEA: BONE GRAFTS AND SUBSTITUTES MARKET ($MILLION), BY APPLICATION, 2014-2022
TABLE 28 BAXTER: COMPANY SNAPSHOT
TABLE 29 BAXTER: OPERATING SEGMENTS
TABLE 30 INTEGRA: COMPANY SNAPSHOT
TABLE 31 INTEGRA: OPERATING SEGMENTS
TABLE 32 STRYKER: COMPANY SNAPSHOT
TABLE 33 STRYKER: OPERATING SEGMENTS
TABLE 34 ZIMMER BIOMET: COMPANY SNAPSHOT
TABLE 35 ZIMMER BIOMET: OPERATING SEGMENTS
TABLE 36 WRIGHT: COMPANY SNAPSHOT
TABLE 37 WRIGHT: OPERATING SEGMENTS
TABLE 38 XTANT MEDICAL: COMPANY SNAPSHOT
TABLE 39 XTANT MEDICAL: OPERATING SEGMENTS
TABLE 40 JOHNSON & JOHNSON: COMPANY SNAPSHOT
TABLE 41 JOHNSON & JOHNSON: OPERATING SEGMENTS
TABLE 42 ARTHREX: COMPANY SNAPSHOT
TABLE 43 ARTHREX: OPERATING SEGMENTS
TABLE 44 MTF: COMPANY SNAPSHOT
TABLE 45 MTF: OPERATING SEGMENTS
TABLE 46 MEDTRONIC: COMPANY SNAPSHOT
TABLE 47 MEDTRONIC: OPERATING SEGMENTS

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