Darting Mouse can Help Improve Bipolar Disorder’s Diagnoses and Treatment

•   November 13,2014
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Bipolar is a brain disorder which leads to change in the individual mood followed by severe depression. It is also known as manic-depressive illness. This illness increases the risk of the individual committing suicide attempts as well as death due to common medical disorders. In the period of the bipolar disorder the individual acts or feels abnormally happy, irritable or energetic.

It has not been clearly stated by the health sectors as to what leads to a brain defect as bipolar in any individual. However, genetic impacts increase the risk of bipolar diseases by 60-80% due to hereditary influences. There are other factors influencing the growth of the disease such as physiological, environmental, neurological and neuroendocrinological.

There have been many researches and innovations in the field of diagnoses and treatment of bipolar disorder. Recent research study from the Vanderbilt University Medical Center suggests that a darting mouse could help to improve the treatment and diagnosis of the two major and most common brain disorders i.e. ADHD and bipolar.

The researchers inserted a rare human genetic variation into a mouse through a dopamine transporter (DAT). The experiment showed that even after the DAT mutation, the mice very surprisingly weren't hyperactive. The mice exhibited an unusual darting behavior, stated the report. "Early on, we could tell which ones carried the mutation by observing this response," said Blakely, Allan D. Bass Professor of Pharmacology. The researchers also stated that due to the stimulant drugs the mice are showing a "rearing" behavior and are electing for an untimely escape strategy. "We wonder whether this may be a sign that their behavior is driven less by searching for clues to appropriate behavior versus acting on innate impulses," said Blakely.

The report on Research Beam titled "Bipolar Disorder (Manic Depression) - Pipeline Review, H2 2014"� is a useful source of information for to understand the bipolar disorder's therapeutic pipeline. The market investors would find it beneficial to pipeline their future strategies based on in-depth market analysis.

The researchers are looking forward for the test on humans soon. "Dopamine has classically been implicated in reward and the ability to detect novelty and to respond to pleasure and to engage in effective social interactions, these mice may give us much better clues as to how these drugs are acting," he said.