2014 Nucleic Acid Testing Market: Strategic Assessments of Leading Suppliers

 Microbiology/Infectious Diseases

 a. Overview

 b. Major Infectious Diseases

 * AIDS

•  Structure and Composition


•  Classification


•  AIDS Origins


•  Animal Lentivirus Systems


•  Virus Receptors


•  HIV Infections in Humans

 - Pathogenesis and Pathology

•  CD4T Lymphocytes and Memory Cells


•  Monocytes and Macrophages


•  Lymphoid Organs


•  Neural Cells


•  Viral Coinfections

 - Clinical Findings

•  Plasma Viral Load


•  Pediatric AIDS

 - Neurologic Disease

 - Opportunistic Infections

 - Cancer

•  Immunity

 - Virus Isolation

 - Serology

 - Viral Nucleic Acid/Antigen Detection

• Epidemiology

 - Worldwide Spread of AIDS

 - United States

 - Routes of Transmission

•   DNA Probes

 - Overview

 - Quantitative PCR

 - In Situ PCR

 - Needed Improvements

  Viral Load/Drug Resistance Testing

•   Genotype and Phenotype Testing


•   Blood Banking Considerations 

* Adenovirus

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs


•   Adeno-Associated Viruses (AAV)

* Anthrax/Bacillus Anthracis

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs

* Babesiosis

•   Background

* BEA and Other Bartonella Diseases

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs

* Chagas Disease

•   Background

 * Campylobacter

•   Background


•   Diagnostic Tests

 - Culture Identification

•   Vaccines and Drugs

* Chlamydia

•   Background

 - Chlamydia psittaci

 - Chlmaydia pneumoniae

 - Chlamydia trachomatis

•   Diagnostic Tests


•   Vaccines and Drugs

* Creutzfeldt-Jakob’s Disease

•   Background


•   Blood Transmission


•   Diagnostic Tests


•   Major Commercial and Academic Players

 - Bayer

 - Disease Sciences/Bio Tec Global

 - Imperial College School of Medicine

 - Ortho-Clinical Diagnostics

 - Pall

 - ProMetic Life Sciences

 - Proteome Sciences/Idexx

 - Q-One Biotech

 - Serono

 - U.S. Agricultural Research Service

•   Drugs


•   Vaccines 

 * Cytomegalovirus

•   Background

 - Chorioretinitis

 - Gastrointestinal

 - Central Nervous System Disease

•   Diagnostic Tests


•   Vaccines and Drugs

* Ebola Virus

•   Background

 - Epidemiology

 - Clinical Syndromes

•   Diagnostic Tests


•   Vaccines and Drugs

 * EchoVirus

•  Background

 - Acute Aseptic Meningitisis

 - Encephalitis

 - Exanthems

 - Respiratory Disease

 - Myopericarditis

 - Neonatal Infections

•   Diagnostic Tests


•   Vaccines and Drugs

* Encephalitis

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs

 * Enteroviruses

•   Background


•   Diagnostic Tests

 - Viral Isolation and Identification

 - Antibody Tests

•   Vaccines and Drugs

 * Epstein-Barr Virus

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs

 * Gonorrhea

•   Background


•   Diagnostic Tests 


•   Vaccines and Drugs

* Hepatitis

•   Hepatitis A


•   Hepatitis B

 - Structure and Composition

 - Replication

•   Hepatitis C


•   Hepatitis D (Delta)


•   Hepatitis E


•   Hepatitis G


•   Hepatitis Infections Pathology


•   Clinical Findings


•   Laboratory Tests

 - Hepatitis A

 - Hepatitis B

 - Hepatitis C

 - Hepatitis D

 - Hepatitis E

•   Virus-Host Immune Reactions


•   Epidemiology

 - Hepatitis A

 - Hepatitis B

 - Hepatitis C

 - Hepatitis D (Delta)

•   Vaccines and Drugs

 * Herpes Simplex Virus

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs

* Legionella

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs

* Lyme Disease

•   Background

 - Clinical Description

 - Clinical Case Definition

 - Laboratory Criteria for Diagnosis

 - Case Classification

•   Diagnostic Tests


•   Vaccines and Drugs

* Malaria 

* Mycoplasma

•   Background

 - Ureaplasma Urealyticum & Mycoplasma Hominis 

•   Diagnostic Tests


•   Vaccines and Drugs

* Papillomaviruses/HPV

•   Background

 - HPV in Cancer

 - Cervical Neoplasm

•   Diagnostic Tests


•   Vaccines and Drugs

 - Prevention

* Parvovirus B19

•   Background

 - Microbiology

 - Epidemiology

 - Clinical Syndromes

 - Erythema Infectiosum (Slapped Cheek)

 - Adult Polyarthropathy

 - Transient Aplastic Crisis

 - Transient Pancytopenia

 - Red Cell Aplasia in Immunocompromised 

 - Perinatal Infections

•   Diagnostic Test


•   Vaccines and Drugs

* Pneumonia

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs

 * Polyomaviruses

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs

 * Salmonellosis

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs

* Shigellosis

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs 

* Streptococci

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs

 - Group A Streptococci

 - Group B Streptococci

 * Toxoplasmosis

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs

 * Tuberculosis

•   Background


•   Diagnostic Tests

 - Microscopic Characteristics

 - Cultural Characteristics

 - Skin Tests

 - MDRTB

•   Vaccines and Drugs

* West Nile Virus

•   Background

 - Clinical Syndromes

•   Diagnostic Tests


•   Vaccines and Drugs

* Yersinia

•   Background


•   Diagnostic Tests


•   Vaccines and Drugs

 * Antibiotic Susceptibility

 Cancer Testing

 a. Overview

 b. Major Cancer Types

  * Prostate

  * Lung 

  * Colon and Rectum

  * Breast

  * Skin

  * Uterine

  * Leukemia

  * Oral

 c. Oncogenes

•   Abl/abl-bcr


•   AIB1


•   BCL-2


•   BRCA1


•   CD44


•   C-fos


•   C-myb


•   C-myc


•   CYP17


•   Erb-B


•   HPC1


•   N-myc


•   P40


•   P51


•   P53


•   PIK3CATable of Contents (continued)


•   PTI-1


•   Ras


•   Reg


•   Sis


•   Src

 Genetic Diseases

 a. Overview

 b. Nucleic Acid Amplification

 c. Chromosome Imaging

 d. Genomics Technologies

 e. Proteomics Technologies

 f. Current Pharmacogenomic Tests

 g. Future Pharmacogenomic Testing

 h. Major Diseases

 * Achondroplasia

 * Autosomal Dominant Polycystic Kidney Disease 

 * Cancer

 * Cosmetogenomics

 * Cystic Fibrosis

 * Down's Syndrome

 * Duchenne and Becker Muscular Dystrophy

  * Factor V (Leiden)

  * Factor IX Deficiency

  * Fragile X Syndrome

  * Heart Disease

  * Hemochomatosis

  * Hemophilia

  * Huntington's Disease

  * Maternal-Fetal Incompatibility

  * Multiple Endocrine Neoplasia

  * Phenylketonuria (PKU)

  * Polycystic Kidney Disease (PKD)

  * Prenatal Screening

  * Retinitis Pigmentosa

  * Retinoblastoma

  * Sickle Cell AnemiaTable of Contents (continued)

  * Spinal Muscular Atrophy

  * Vitamin B12 Metabolism

 i. Social Issues and Concerns

 Forensic Testing 

 a. Overview

 b. Multilocus and Single Locus Probes

 * Multilocus Probes

 * Single Locus Probes

 * PCR and RFLP

 c. The FBI

 d. DNA Profile Data Banks

 * U.S.A.

 * U.K.

 e. Judicial Implementation

 f. Major Crime Categories

 g. Factors Contributing to the DNA Probe Market Expansion 

 * Technology Availability

 * Use of Hair as Evidence

 h. Wildlife Forensics

 Paternity Testing/HLA Typing

 Other Applications

 a. Disease Susceptibility Testing

 b. Cardiovascular Diseases

 c. Diabetes

 d. Alzheimer's Disease

 e. Periodontal Disease

 f. Plasma Purification

 g. Organ Transplantation

 h. Water Contamination

 i. Other

Competitive Profiles

 

- Abbott

- Affymetrix

- Agilent

- Applied Gene Technologies

- Arca

- Beckman Coulter/DanaherTable of Contents (continued)

- Becton Dickinson

- Biokit

- BioMerieux

- Bio-Rad

- Biotest

- Caliper

- Cepheid

- Decode 

- Diadexus 

- Eiken

- Enzo

- Exact Sciences

- Fujirebio

- Gen-Probe

- Hologic

- Illumina

- Innogenetics/Solvay

- Kreatech

- Li-Cor Biosciences

- Life Technologies

- Monogram Biosciences

- Myriad Genetics

- Nanogen/Elitech

- Novartis

- Orchid CellMark

- Ortho-Clinical Diagnostics

- Proteome Sciences

- Qiagen

- Roche

- Scienion

- Sequenom

- Shimadzu

- Siemens

- Sierra Molecular

- Takara Bio

- Tecan GroupList of Tables

Major Companies Developing or Marketing AIDS Molecular

Diagnostic And Other Direct Identification Tests

Major Companies Developing or Marketing Adenovirus

Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Campylobacter

Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Chlamydia

Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing CMV Molecular

Diagnostic And Other Direct Identification Tests

Major Companies Developing or Marketing EBV Molecular

Diagnostic And Other Direct Identification Tests

Major Companies Developing or Marketing Gonorrhea

Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Hepatitis

Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Herpes

Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Legionella

Molecular Diagnostic And Other Direct

Identification TestsList of Tables (continued)

Major Companies Developing or Marketing Lyme

Disease Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Mycoplasma

Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Papilloma

Virus Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Pneumonia

Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Salmonella

Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Shigella

Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Streptococci 

Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Toxoplasmosis

Molecular Diagnostic And Other Direct

Identification Tests

Major Companies Developing or Marketing Tuberculosis

Molecular Diagnostic And Other Direct

Identification TestsList of Tables (continued)

Oncogenes Potential Application in Cancer Diagnosis

Major Companies Developing or Marketing Cancer

Molecular Diagnostic Tests

Major Companies Developing or Marketing Molecular

Diagnostic Test For Genetic Diseases

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